Shopping Cart

Remove All
Your shopping cart is currently empty

Proceed to checkout Continue shopping

Viral Proteins

Coronavirus (CoV) Proteins

HCV Proteins

The hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae. HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated HCC) and lymphomas in humans. HCV particle consists of a lipid membrane envelope that is 55 to 65 nm in diameter. Two viral envelope glycoproteins, E1 and E2, are embedded in the lipid envelope. They take part in viral attachment and entry into the cell. Within the envelope is an icosahedral core that is 33 to 40 nm in diameter. Inside the core is the RNA material of the virus. HCV is predominantly a blood-borne virus, with very low risk of sexual or vertical transmission.

Filter HomeRecombinant ProteinsViral ProteinsHCV Proteins

Hepatitis C Genome polyprotein (His)

TMPH-00809

Expression system: E. coli
Length: 1-631, Full Length
Activity: Not Tested

$129

20 days

Size

QTY

Buffer-exchangeable

Hepatitis C virus (HCV-1a) E2 Protein (His)

TMPY-01564

Expression system: HEK293 Cells
Length: 1-278, Partial
Activity: Not Tested

7-10 days

Size

QTY

SPR-compatible buffer

Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His)

TMPY-04135

Expression system: HEK293 Cells
Length: 192-340, Partial
Activity: Not Tested

7-10 days

Size

QTY

SPR-compatible buffer

Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His)

TMPY-00296

Expression system: HEK293 Cells
Length: 384-661, Partial
Activity: Not Tested

7-10 days

Size

QTY

SPR-compatible buffer

Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)

TMPY-00323

HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. One of the HCV proteases, NS3-4A serine protease, is a non-covalent heterodimer consisting of a catalytic subunit (the N-terminal one-third of NS3 protein) and an activating cofactor (NS4A protein) and is responsible for cleavage at four sites of the HCV polyprotein.

7-10 days

Size

QTY