CDK13 Protein, Human, Recombinant (GST)

Name: CDK13 Protein, Human, Recombinant (GST)
Brand: TargetMol
SKU: TMPC-00131
Rating: 4.5 (1 reviews)

(Synonyms: KIAA1791, hCDK13, Cyclin-dependent kinase 13, CHED, CDK13, CDC2L5, CDC2L) Copy Product Info

Synonyms: KIAA1791, hCDK13, Cyclin-dependent kinase 13, CHED, CDK13, CDC2L5, CDC2L

Catalog No. TMPC-00131 Copy Product Info

CDK13 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q14004.

Pack Size	Price	USA Stock	Global Stock	Quantity
20 µg	$953	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	CDK13 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q14004.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	Q14004
Construction	Recombinant human CDK13 (516-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>70% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Synonyms	KIAA1791, hCDK13, Cyclin-dependent kinase 13, CHED, CDK13, CDC2L5, CDC2L
Research Background	cyclin-dependent kinase 12 (CDK12) and 13 evolved by duplication of a common gene ancestor, a single paralog being found in non-vertebrates deuterostomes. In mammalian cells, both kinases operate in separate complexes, which could have different functions. CDK13 is localised in the nucleus and particularly in speckles, the storage site for splicing factors. CDK13 plays a role in splicing regulation by controlling the phosphorylation status and the activity of splicing factors. CDK13 interacts with p32 a protein associating with the splicing factor SRSF1 (also known as ASF/SF2). Through its association with p32 and by phosphorylating SRSF1, CDK13 increases the mRNA splicing of human immunodeficient virus type 1 (HIV-1) and its overexpression, suppresses virus production.

Chemical Properties

Molecular Weight

~160 kDa

Storage & Solubility Information

Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.