Activity has not been tested. It is theoretically active, but we cannot guarantee it.

CDK13 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q14004.

Human

Baculovirus-Insect Cells

KIAA1791,hCDK13,Cyclin-dependent kinase 13,CHED,CDK13,CDC2L5,CDC2L

Recombinant human CDK13 (516-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

>70% as determined by SDS-PAGE.

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

cyclin-dependent kinase 12 (CDK12) and 13 evolved by duplication of a common gene ancestor, a single paralog being found in non-vertebrates deuterostomes. In mammalian cells, both kinases operate in separate complexes, which could have different functions. CDK13 is localised in the nucleus and particularly in speckles, the storage site for splicing factors. CDK13 plays a role in splicing regulation by controlling the phosphorylation status and the activity of splicing factors. CDK13 interacts with p32 a protein associating with the splicing factor SRSF1 (also known as ASF/SF2). Through its association with p32 and by phosphorylating SRSF1, CDK13 increases the mRNA splicing of human immunodeficient virus type 1 (HIV-1) and its overexpression, suppresses virus production.