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1,3-Dicaffeoylquinic acid

Name: 1,3-Dicaffeoylquinic acid
Brand: TargetMol
SKU: T5736
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5736Cas No. 19870-46-3

Alias CYNARIN, Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-, 1,5-Dicaffeoylquinic acid, 1,3-O-Dicaffeoylquinic acid

1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.

1,3-Dicaffeoylquinic acid

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Purity: 98.81%

Catalog No. T5736Alias CYNARIN, Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-, 1,5-Dicaffeoylquinic acid, 1,3-O-Dicaffeoylquinic acidCas No. 19870-46-3

1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$232	In Stock	In Stock
100 mg	$343	-	In Stock
200 mg	$497	-	In Stock
1 mL x 10 mM (in DMSO)	$110	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.81%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
In vivo	CYNARIN have neuroprotective effects.CYNARIN prevents Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
Animal Research	The neuroprotective effects of 1,5-DQA against amyloid β(1-42) (Aβ(42))-induced neurotoxicity in primary neuronal culture. To evaluate the neuroprotective effects of 1,5-DQA, primary cultured cortical neurons from neonate rats were pretreated with 1,5-DQA for 2 hours and then treated with 40 μmol/L Aβ(42) for 6 hours. Cell counting kit-8, Hoechst staining and Western blotting were used for detecting the protective mechanism. Comparisons between two groups were evaluated by independent t test, and multiple comparisons were analyzed by one-way analysis of variance (ANOVA).
Synonyms	CYNARIN, Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-, 1,5-Dicaffeoylquinic acid, 1,3-O-Dicaffeoylquinic acid

Chemical Properties

Molecular Weight	516.45
Formula	C₂₅H₂₄O₁₂
Cas No.	19870-46-3
Smiles	O[C@@H]1C[C@@](C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@@H]1O)(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
Relative Density.	1.64 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (464.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9363 mL	9.6815 mL	19.3630 mL	96.8148 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL	19.3630 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL	9.6815 mL
20 mM	0.0968 mL	0.4841 mL	0.9681 mL	4.8407 mL
50 mM	0.0387 mL	0.1936 mL	0.3873 mL	1.9363 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.9681 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc