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BMS-599626 2HCL(714971-09-2 Free base)

Catalog No. T2610L CAS 1781932-33-9

Synonyms: BMS 599626 dihydrochloride, BMS-599626 2HCL(714971-09-2 Free base), AC480 2HCl

BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.

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BMS-599626 2HCL(714971-09-2 Free base) Chemical Structure

BMS-599626 2HCL(714971-09-2 Free base), CAS 1781932-33-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 86.00
5 mg	In stock	$ 153.00
10 mg	In stock	$ 298.00
25 mg	In stock	$ 513.00
50 mg	In stock	$ 743.00
100 mg	In stock	$ 1,050.00
1 mL * 10 mM (in DMSO)	In stock	$ 351.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.
Targets&IC50	HER2:30 nM, HER1:20 nM, HER4:190 nM
In vitro	BMS-599626 is a potent HER inhibitor and has a higher inhibition ability than the other reported inhibitors. When tested with breast tumor cell lines (HCC202, HCC1942 and AU565) that highly expressed HER1 and HER2, BMS-599626 treatment inhibited cell proliferation, while having no effect on A2780 cells without HER1 or HER2 expression.[1] Treated OV202 cells with BMS-599626 significantly inhibited cell proliferation and enhanced cell apoptosis by inhibiting HER.[3] When tested with Sal2 cells expressing CD8-HER2 fusion protein, BMS-599626 treatment inhibited the receptor phosphorylation and MAPK phosphorylation with the IC50 value of 0.3 and 0.22 μM/L, respectively.[1]
In vivo	In mouse models with Sal2 tumor cells xenograft, oral administration of BMS-599626 inhibited Sal2 cells growth in a dose-dependent manner and significantly delayed tumor growth at the concentration of 60 mg/kg.[1]

Synonyms	BMS 599626 dihydrochloride, BMS-599626 2HCL(714971-09-2 Free base), AC480 2HCl
Molecular Weight	603.47
Formula	C27H29Cl2FN8O3
CAS No.	1781932-33-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (41.43 mM)

References and Literature

1. Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006;12(20 Pt 1):6186-6193. 2. Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011;29(4):554-561. 3. Haluska P, et al. HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Mol Cancer Ther. 2008;7(9):2589-2598.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

HER2/neu (654-662) GP2 acetate Sulfatinib BMS 599626 2HCl (873837-23-1(HCl)) Terfenadine O-Nornuciferine SU5204 SYR127063 Neratinib

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Keywords

BMS-599626 2HCL(714971-09-2 Free base) 1781932-33-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors HER BMS-599626 Dihydrochloride BMS 599626 dihydrochloride BMS 599626 Dihydrochloride AC-480 BMS599626 BMS599626 Dihydrochloride BMS 599626 BMS 599626 dihydrochloride (714971-09-2 free base) BMS-599626 AC480 2HCl AC 480 AC480 inhibitor inhibit

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