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Ulocuplumab

Catalog No. T76794 CAS 1375830-34-4

Synonyms: BMS 936564, MDX 1338

Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplumab inhibits the migration of chronic lymphocytic leukemia (CLL) cells under CXCR4 activation, induces apoptosis, and inhibits the growth and migration of cancer cells. Ulocplumab inhibits CXCL12-mediated chronic lymphocytic leukemia (CLL) cell migration in response to CXCR4 activation and induces apoptosis.)

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Ulocuplumab

Ulocuplumab, CAS 1375830-34-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 247.00
5 mg	In stock	$ 708.00
10 mg	In stock	$ 987.00

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Description	Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplumab inhibits the migration of chronic lymphocytic leukemia (CLL) cells under CXCR4 activation, induces apoptosis, and inhibits the growth and migration of cancer cells. Ulocplumab inhibits CXCL12-mediated chronic lymphocytic leukemia (CLL) cell migration in response to CXCR4 activation and induces apoptosis.)
Targets&IC50	Ramos cells:10 nM
In vitro	Ulocuplumab (0-100 μM; 48 h) lacks antibody-dependent cell-mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) activity. However, it induces CXCR4-binding-mediated apoptosis in Ramos cells and CLL or cancer cell lines. It also demonstrates pro-apoptotic effects in primary leukemia cells from CLL patients [1]. Ulocuplumab (0.2 μM, 2 μM; 15 s) inhibits F-actin polymerization, reduces peak responses to CXCL12, and (20 nM-2 μM; 1 h) additionally inhibits cell migration [1]. At a concentration of 200 nM for 6 hours, Ulocuplumab induces programmed cell death (PCD) independently of caspases [1]. Ulocuplumab (10 μg/mL; 4 h) induces cell death in CLL cells by generating reactive oxygen species (ROS) [1]. Ulocuplumab inhibits CXCL12-induced calcium flux, with an EC50 of 10 nM in Ramos cells [2].
In vivo	Ulocuplumab (3-30 mg/kg; intraperitoneal injection; 5 doses over 3-4 days; a total of 65 days) inhibits tumor growth in a murine multiple myeloma xenograft model, including tumor models with Ramos B cells, HL-60 cells, MOLP-8 cells, Nomo-1 cells, and JJN-3R cells [1].

Synonyms	BMS 936564, MDX 1338
Molecular Weight	146.2 (kDa)
CAS No.	1375830-34-4

Storage

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store at -20°C

References and Literature

1. Kashyap MK, et al. Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. Oncotarget. 2016 Jan 19;7(3):2809-22. 2. Kuhne MR, et al. BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19(2):357-66.

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Keywords

Ulocuplumab 1375830-34-4 Apoptosis Autophagy GPCR/G Protein Immunology/Inflammation CXCR BMS 936564 MDX1338 BMS-936564 MDX-1338 BMS936564 MDX 1338 inhibitor inhibit

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