Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

GPX4-IN-19

Name: GPX4-IN-19
Brand: TargetMol
SKU: T210521
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T210521Cas No. 3102894-57-2

GPX4-IN-19 is a highly effective small-molecule inhibitor of glutathione peroxidase 4 (GPX4) with an IC50 value of 0.311 μM, which exerts its pharmacological activity by covalently binding to the Sec46 active site of GPX4, thereby disrupting lipid peroxide detoxification, inducing intracellular Fe²⁺ accumulation, elevating lipid peroxide (LPO) and reactive oxygen species (ROS) levels, triggering ferroptosis-associated DNA damage, demonstrating strong anti-proliferative effects with high ferroptosis selectivity, and providing a robust experimental tool for mechanistic and therapeutic studies in Triple-Negative Breast Cancer (TNBC).

GPX4-IN-19

🥰Excellent

Purity: 99.97%

Catalog No. T210521Cas No. 3102894-57-2

Product information is being updated, if you want to purchase, please click the bulk custom button.

Add to Quotation

Questions

Batch Information

Select Batch

Purity:99.97%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GPX4-IN-19 is a highly effective small-molecule inhibitor of glutathione peroxidase 4 (GPX4) with an IC50 value of 0.311 μM, which exerts its pharmacological activity by covalently binding to the Sec46 active site of GPX4, thereby disrupting lipid peroxide detoxification, inducing intracellular Fe²⁺ accumulation, elevating lipid peroxide (LPO) and reactive oxygen species (ROS) levels, triggering ferroptosis-associated DNA damage, demonstrating strong anti-proliferative effects with high ferroptosis selectivity, and providing a robust experimental tool for mechanistic and therapeutic studies in Triple-Negative Breast Cancer (TNBC).
Targets&IC50	GPX4:0.311 μM
In vivo	Method: GPX4-IN-19 was administered intraperitoneally at 5 or 10 mg/kg every two days for 24 days in MDA-MB-231 tumor-bearing mice. Result: GPX4-IN-19 produced dose-dependent tumor growth inhibition without significant toxicity or weight loss[1].

Chemical Properties

Molecular Weight	395.81
Formula	C₁₉H₁₉ClFNO₅
Cas No.	3102894-57-2
Smiles	O=C(N(C1=CC(OC)=C(F)C(OC)=C1)CC2=CC=C3OCCOC3=C2)CCl
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (101.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5265 mL	12.6323 mL	25.2646 mL	126.3232 mL
5 mM	0.5053 mL	2.5265 mL	5.0529 mL	25.2646 mL
10 mM	0.2526 mL	1.2632 mL	2.5265 mL	12.6323 mL
20 mM	0.1263 mL	0.6316 mL	1.2632 mL	6.3162 mL
50 mM	0.0505 mL	0.2526 mL	0.5053 mL	2.5265 mL
100 mM	0.0253 mL	0.1263 mL	0.2526 mL	1.2632 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc