Mps1-IN-1 dihydrochloride

Name: Mps1-IN-1 dihydrochloride
Brand: TargetMol
SKU: T70095
Rating: 4.5 (1 reviews)

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Catalog No. T70095Cas No. 1883548-93-3

Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and 'normal' cells.

Mps1-IN-1 dihydrochloride

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Catalog No. T70095Cas No. 1883548-93-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$1,390	35 days	35 days

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Product Introduction

Bioactivity

Description	Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and 'normal' cells.
Targets&IC50	CLK1:1900 nM (Kd), PYK2:280 nM (Kd), TNK1:2600 nM (Kd), ERK2:2900 nM (Kd), TYK1/LTK:29 nM (Kd), ALK:21 nM (Kd), Insulin receptor:470 μM (Kd), IGF-1R:750 nM (Kd), Mps1:27 nM (Kd), Mps1:367 nM, GAK:1100 nM (Kd), TNK2:3100 nM (Kd), FAK:440 nM (Kd), Insulin receptor related receptor:1200 nM (Kd)

Chemical Properties

Molecular Weight	608.58
Formula	C₂₈H₃₅Cl₂N₅O₄S
Cas No.	1883548-93-3
Smiles	Cl.Cl.O=S(=O)(C=1C=CC=CC1NC=2C=C(N=C3NC=CC32)NC4=CC=C(C=C4OC)N5CCC(O)CC5)C(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc