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Mps1-IN-1 dihydrochloride

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Catalog No. T70095Cas No. 1883548-93-3

Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and 'normal' cells.

Mps1-IN-1 dihydrochloride
Other Forms of Mps1-IN-1 dihydrochloride:
Mps1-IN-1T121021125593-20-5
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Mps1-IN-1 dihydrochloride

😃Good
Catalog No. T70095Cas No. 1883548-93-3
Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and 'normal' cells.
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10 mgTBD35 days
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Product Introduction

Bioactivity
Description
Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM. It effectively inhibits the activity of Mps1 mitotic kinase and disrupts spindle assembly checkpoint (SAC) function, thereby reducing the viability of both cancerous and 'normal' cells.
Targets&IC50
PYK2:280 nM (Kd), INSR:470 μM (Kd), FAK:440 nM (Kd), GAK:1100 nM (Kd), Mps1:27 nM (Kd), TYK1/LTK:29 nM (Kd), IGF-1R:750 nM (Kd), TNK1:2600 nM (Kd), ERK2:2900 nM (Kd), CLK1:1900 nM (Kd), TNK2:3100 nM (Kd), Mps1:367 nM, INSRR:1200 nM (Kd), ALK:21 nM (Kd)
Chemical Properties
Molecular Weight608.58
FormulaC28H35Cl2N5O4S
Cas No.1883548-93-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

Mps1-IN-1 DihydrochlorideMps1-IN-1AEG40730 dihydrochlorideAEG-40730AEG40730AEG 40730
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