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2BAct

🥰Excellent
Catalog No. T9149Cas No. 2143542-28-1
Alias 2B-Act, 2B Act

2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response

2BAct

2BAct

🥰Excellent
Purity: 99.04%
Catalog No. T9149Alias 2B-Act, 2B ActCas No. 2143542-28-1
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$53In StockIn Stock
5 mg$133In StockIn Stock
10 mg$213In StockIn Stock
25 mg$353In StockIn Stock
50 mg$495In StockIn Stock
100 mg$678In StockIn Stock
1 mL x 10 mM (in DMSO)$155In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.04%
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Product Introduction

Bioactivity
Description
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
Targets&IC50
eIF2B:33 nM (EC50)
Synonyms2B-Act, 2B Act
Chemical Properties
Molecular Weight440.8
FormulaC19H16ClF3N4O3
Cas No.2143542-28-1
SmilesFC(F)c1cnc(cn1)C(=O)NC12CC(C1)(C2)NC(=O)COc1ccc(Cl)c(F)c1
Relative Density.1.53 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 240 mg/mL (544.46 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.34 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2686 mL11.3430 mL22.6860 mL113.4301 mL
5 mM0.4537 mL2.2686 mL4.5372 mL22.6860 mL
10 mM0.2269 mL1.1343 mL2.2686 mL11.3430 mL
20 mM0.1134 mL0.5672 mL1.1343 mL5.6715 mL
50 mM0.0454 mL0.2269 mL0.4537 mL2.2686 mL
100 mM0.0227 mL0.1134 mL0.2269 mL1.1343 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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