CCT365623 hydrochloride

Name: CCT365623 hydrochloride
Brand: TargetMol
SKU: T10719
Rating: 4.5 (1 reviews)

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Catalog No. T10719Cas No. 2126136-98-7

CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.

CCT365623 hydrochloride

😃Good

Catalog No. T10719Cas No. 2126136-98-7

CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	1-2 weeks	1-2 weeks
50 mg	$2,380	1-2 weeks	1-2 weeks
100 mg	$3,100	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.
Targets&IC50	LOX:0.89 μM
In vitro	CCT365623 inhibits LOX at approximately 5 μM in the biosensor system. CCT365623 (0-40 μM) decreases surface EGFR protein levels in a concentration-dependent manner, disrupts HTRA1 multimerization, activates [TGFβ1] signaling, suppresses MATN2 expression, and reduces EGFR surface retention and signaling. At 5 μM, CCT365623 decreases pY1068 EGFR, pAKT, and MATN2 protein levels, while increasing pSMAD2 protein levels.
In vivo	CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cells. CCT365623 exhibits a T1/2PO of 0.6 h and F% (oral bioavailability) of 45%.

Chemical Properties

Molecular Weight	443.99
Formula	C₁₈H₁₈ClNO₄S₃
Cas No.	2126136-98-7
Smiles	Cl.CS(=O)(=O)c1cc(cc(c1)S(=O)(=O)c1ccc(CN)s1)-c1ccccc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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