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BIMU 8

Name: BIMU 8
Brand: TargetMol
SKU: T21946
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21946Cas No. 134296-40-5

BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.

BIMU 8

🥰Excellent

Purity: 99.87%

Catalog No. T21946Cas No. 134296-40-5

BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.

Pack Size	Price	Availability
1 mg	$82	In Stock
5 mg	$181	In Stock
10 mg	$262	In Stock
25 mg	$438	In Stock
50 mg	$647	In Stock
100 mg	$919	In Stock
500 mg	$1,860	In Stock
1 mL x 10 mM (in DMSO)	$195	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.87%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.
Targets&IC50	5-HT4 Receptor (T3.36A):77 nM (EC50), 5-HT4 receptor:18 nM (EC50), 5-HT4 Receptor (W6.48A):540 nM (EC50)
In vitro	BIMU 8 (0.003-0.1 µM) increases excitatory postsynaptic potentials amplitude without changing the membrane potential of any neuron in myenteric neurons of guinea pig ileum[1].
In vivo	BIMU 8 (20-30 mg/kg s.c. and 60 mg/kg p.o. in mice; 20 mg/kg i.p. in rats), produces significant antinociception. In mice, BIMU 8 (10 μg; i.c.v) which is largely ineffective by parenteral routes induces antinociception[2].

Chemical Properties

Molecular Weight	378.9
Formula	C₁₉H₂₇ClN₄O₂
Cas No.	134296-40-5
Smiles	Cl.CC(C)n1c2ccccc2n(C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c1=O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (118.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6392 mL	13.1961 mL	26.3922 mL	131.9609 mL
5 mM	0.5278 mL	2.6392 mL	5.2784 mL	26.3922 mL
10 mM	0.2639 mL	1.3196 mL	2.6392 mL	13.1961 mL
20 mM	0.1320 mL	0.6598 mL	1.3196 mL	6.5980 mL
50 mM	0.0528 mL	0.2639 mL	0.5278 mL	2.6392 mL
100 mM	0.0264 mL	0.1320 mL	0.2639 mL	1.3196 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc