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GW-1100

Name: GW-1100
Brand: TargetMol
SKU: T15448
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15448Cas No. 306974-70-9

Alias GW1100, GW 1100

GW-1100 is a selective GPR40 and FFAR1 antagonist for the study of diabetes and metabolic diseases.

GW-1100

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Purity: 97.01%

Catalog No. T15448Alias GW1100, GW 1100Cas No. 306974-70-9

GW-1100 is a selective GPR40 and FFAR1 antagonist for the study of diabetes and metabolic diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.01%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	GW-1100 is a selective GPR40 and FFAR1 antagonist for the study of diabetes and metabolic diseases.
Targets&IC50	FFA1/GPR40:6.9 (pic50)
In vitro	GW-1100 (1 μM) caused a significant right shift in the concentration-response curve of GW9508 (pEC50=7.17±0.08 in the absence, pEC50=6.79±0.09P<0.05 in the presence of 1 μM GW-1100; n=3); At GW-1100 concentrations (3 μM and above), the maximum response is significantly reduced, and the pEC50 response continues to shift to the right [2]; CHO-K1/bFFAR1 cells were incubated with 10 μM GW1100 or vehicle (0.1% DMSO) for 15 minutes, and then Stimulated with vehicle, oleic acid, linoleic acid, or GW9508. GW-1100 significantly reduced 300 μM oleic acid (AUC(60-150 s), p<0.05), 100 μM linoleic acid (AUC(60-150 s), p<0.05) and 10 μM GW9508 (AUC( 60 - 150 s), p<0.05); GW-1100 dose-dependently inhibited the GW9508- and linoleic acid-stimulated GPR40-mediated increase in Ca2+ (pIC50: 5.99±0.03 and 5.99±0.06)[3].
In vivo	Intracerebroventricular administration of DHA (50 µg) and GW9508 (1.0 µg) significantly reduced mechanical and thermal hyperalgesia on day 7, but not on day 1, after CFA administration. These effects were inhibited by intracerebroventricular administration of the GPR40 antagonist GW-1100 (10 µg) [4].
Synonyms	GW1100, GW 1100

Chemical Properties

Molecular Weight	520.58
Formula	C₂₇H₂₅FN₄O₄S
Cas No.	306974-70-9
Smiles	CCOC(=O)c1ccc(cc1)-n1cc(Cc2cnc(OCC)nc2)c(=O)nc1SCc1ccc(F)cc1
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (57.63 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (Insoluble.)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (3.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9209 mL	9.6047 mL	19.2093 mL	96.0467 mL
5 mM	0.3842 mL	1.9209 mL	3.8419 mL	19.2093 mL
10 mM	0.1921 mL	0.9605 mL	1.9209 mL	9.6047 mL
20 mM	0.0960 mL	0.4802 mL	0.9605 mL	4.8023 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc