GDF-15 Protein, Human, Recombinant (E. coli, His)

Catalog No. TMPY-04727U

GDF-15 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is Q99988-1.

GDF-15 Protein, Human, Recombinant (E. coli, His)

Catalog No. TMPY-04727U

GDF-15 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is Q99988-1.

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Product Information

Biological Activity	Immobilized Human GDF15, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC50 of 11.5 ng/ml determined by ELISA. Human GFRAL, hFc Tag captured on CM5 Chip via Protein A can bind Human GDF15, His Tag with an affinity constant of 0.014 nM as determined in SPR assay (Biacore T200).
Description	GDF-15 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is Q99988-1.
Species	Human
Expression System	E. coli
Accession Number	Q99988-1
Synonyms	PTGFB,PLAB,PDF,NAG-1,MIC-1,MIC1,growth differentiation factor 15,GDF-15
Construction	Ala197-Ile308
Protein Purity	> 95% as determined by Tris-Bis PAGE
Molecular Weight	13.5 kDa (Predicted); 15-16 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in 50 mM HAc (pH 2.9). Normally 8% trehalose is added as protectant before lyophilization.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.