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Anti-TREX1 Antibody (9A314) (Synonyms: TREX1, Three-prime repair exonuclease 1, Deoxyribonuclease III (DNase I...)
Catalog No. TMAC-04114 Copy Product Info
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Anti-TREX1 Antibody (9A314) is a Rabbit antibody targeting TREX1. Anti-TREX1 Antibody (9A314) can be used in ICC,IF,IHC,WB.
Anti-TREX1 Antibody (9A314)
Copy Product Info🥰Excellent
Catalog No. TMAC-04114
Synonyms TREX1, Three-prime repair exonuclease 1, Deoxyribonuclease III (DNase III), 3'-5' exonuclease TREX1
Anti-TREX1 Antibody (9A314) is a Rabbit antibody targeting TREX1. Anti-TREX1 Antibody (9A314) can be used in ICC,IF,IHC,WB.
Anti-TREX1 Antibody
(9A314)
(9A314)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $298 | 7-10 days | 7-10 days | |
| 100 μL | $497 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-TREX1 Antibody (9A314) is a Rabbit antibody targeting TREX1. Anti-TREX1 Antibody (9A314) can be used in ICC,IF,IHC,WB. |
| Synonyms | TREX1, Three-prime repair exonuclease 1, Deoxyribonuclease III (DNase III), 3'-5' exonuclease TREX1 |
| Ig Type | IgG |
| Clone | 9A314 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of TREX1 on different cell lysates using anti-TREX1 at 1/500 dilution. Positive control: Line 1: A431, Line 2: SK-Br-3. 2. Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-TREX1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue using anti-TREX1 antibody. Counter stained with hematoxylin. 4. ICC staining TREX1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining TREX1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining TREX1 in SiHa cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.       |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: human TREX1 aa 100-300 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 34 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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