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Serotonin

Name: Serotonin
Brand: TargetMol
SKU: TN2437
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2437Cas No. 50-67-9

Alias 5-hydroxytryptamine, 5-HT

Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin regulates the nervous system, digestive system and cardiovascular system.

Serotonin

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Purity: 99.98%

Catalog No. TN2437Alias 5-hydroxytryptamine, 5-HTCas No. 50-67-9

Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin regulates the nervous system, digestive system and cardiovascular system.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$428	-	In Stock
1 mL x 10 mM (in DMSO)	$38	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.98%

Appearance:Solid

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin regulates the nervous system, digestive system and cardiovascular system.
Targets&IC50	5-HT1A:117 nM (EC50)
In vitro	METHODS: Mouse B16 melanoma cells were treated with Serotonin for 2 days to detect the anti-melanin production activity. RESULTS: Serotonin is slightly active or inactive in the inhibitory medium dimming, with IC50> 30 μM. [1]
In vivo	METHODS: To study the pain hypersensitivity of Serotonin, Serotonin (10 uM; 20 μl was intradermal injected into mice, and the mice were tested at 15, 30, 45, 60, 90, 120, 180 and 240 minutes. RESULTS: Compared with the control group receiving saline treatment, Serotonin produced a strong hypersensitivity reaction (p<0.001). [2] METHODS: To study the role of IL-13-mediated 5-HT signaling in the pathogenesis of colitis, Serotonin (100 mg/kg) was subcutaneously injected into male IL-13-deficient mice 3 days before induction of DSS colitis, twice a day for 8 consecutive days. RESULTS: After inducing DSS colitis, the content of 5-HT in the colon of IL-13-/- mice that received Serotonin increased significantly. [3]
Synonyms	5-hydroxytryptamine, 5-HT

Chemical Properties

Molecular Weight	176.22
Formula	C₁₀H₁₂N₂O
Cas No.	50-67-9
Smiles	NCCc1c[nH]c2ccc(O)cc12
Relative Density.	1.1102 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (1447.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (18.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6747 mL	28.3736 mL	56.7472 mL	283.7362 mL
5 mM	1.1349 mL	5.6747 mL	11.3494 mL	56.7472 mL
10 mM	0.5675 mL	2.8374 mL	5.6747 mL	28.3736 mL
20 mM	0.2837 mL	1.4187 mL	2.8374 mL	14.1868 mL
50 mM	0.1135 mL	0.5675 mL	1.1349 mL	5.6747 mL
100 mM	0.0567 mL	0.2837 mL	0.5675 mL	2.8374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc