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LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated
(Synonyms: Protein FDC, Lymphocyte activation gene 3 protein, LAG-3, LAG3, CD223) Copy Product InfoSynonyms: Protein FDC, Lymphocyte activation gene 3 protein, LAG-3, LAG3, CD223
Catalog No. TMPJ-00321 Copy Product Info
LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-70 KDa and the accession number is P18627.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $129 | 35 days | 35 days | |
| 10 µg | $213 | 35 days | 35 days | |
| 20 µg | $355 | 35 days | 35 days | |
| 50 µg | $625 | 35 days | 35 days | |
| 100 µg | $963 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Loaded Anti-Human LAG-3 mAb-Fc on Protein A Biosensor, can bind Biotinylated Human LAG-3-6His-Avi with an affinity constant of 0.17 nM as determined in BLI assay. (Regularly tested) |
| Description | LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-70 KDa and the accession number is P18627. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis-Avi |
| Accession Number | P18627 |
| Amino Acid | Leu23-Leu450 |
| Construction | Leu23-Leu450 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | Protein FDC, Lymphocyte activation gene 3 protein, LAG-3, LAG3, CD223 |
| Research Background | Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4. |
| Molecular Weight | 60-70 KDa (reducing condition) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated chemical structure | LAG-3 Protein, Human, Recombinant (His & Avi), Biotinylated molecular weight
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