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Pheniramine maleate

Name: Pheniramine maleate
Brand: TargetMol
SKU: T0370
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0370Cas No. 132-20-7

Alias Trimetose, Inhiston, Daneral

Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.

Pheniramine maleate

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Purity: 99.85%

Catalog No. T0370Alias Trimetose, Inhiston, DaneralCas No. 132-20-7

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$34	In Stock	In Stock
500 mg	$73	In Stock	In Stock
1 g	$96	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.
Targets&IC50	H1 Receptor:1.01 mM
In vivo	Pheniramine maleate binds to histamine H1 receptors, which inhibits the production of phospholipase A2 and the endothelium-derived relaxing factor NO. This leads to a reduction in the activation of guanylate cyclase due to NO deficiency, resulting in decreased levels of cyclic GMP (cGMP). Consequently, this suppresses the contraction of smooth muscle tissues, reduces capillary permeability, and diminishes histamine-induced allergic responses.
Synonyms	Trimetose, Inhiston, Daneral

Chemical Properties

Molecular Weight	356.42
Formula	C₁₆H₂₀N₂·C₄H₄O₄
Cas No.	132-20-7
Smiles	CN(C)CCC(c1ccccc1)c1ccccn1.C(=C\C(=O)O)\C(=O)O
Relative Density.	1.2233 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 65 mg/mL (182.37 mM), Sonication is recommended.

Ethanol: 66 mg/mL (185.17 mM), Sonication is recommended.

DMSO: 40 mg/mL (112.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8057 mL	14.0284 mL	28.0568 mL	140.2839 mL
5 mM	0.5611 mL	2.8057 mL	5.6114 mL	28.0568 mL
10 mM	0.2806 mL	1.4028 mL	2.8057 mL	14.0284 mL
20 mM	0.1403 mL	0.7014 mL	1.4028 mL	7.0142 mL
50 mM	0.0561 mL	0.2806 mL	0.5611 mL	2.8057 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc