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Carbocisteine
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Catalog No. T3612Cas No. 2387-59-9
Alias S-Carboxymethyl-L-cysteine, Mucodyne, Carbocysteine, Broncodeterge
Carbocisteine (Mucodyne) is commonly used as an anti-infective nasal spray with mucolytic and expectorant effects.
Carbocisteine
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Purity: 99.93%
Catalog No. T3612Alias S-Carboxymethyl-L-cysteine, Mucodyne, Carbocysteine, BroncodetergeCas No. 2387-59-9
Carbocisteine (Mucodyne) is commonly used as an anti-infective nasal spray with mucolytic and expectorant effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 g | $30 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
Carbocisteine AI Summary
Carbocisteine exhibits a diverse range of pharmacological activities. It acts as an inhibitor of the Eg5 protein by inhibiting ATP hydrolysis with an IC50 greater than 63,000 nM, and demonstrates cytotoxic activity against HeLa cells with an IC50 greater than 50,000 nM. In terms of enzyme inhibition, the compound shows no activity against human recombinant UGT1A6 and UGT1A9 enzymes.
Moderate liver toxicity is observed, indicated by elevated ALT or AST serum activity during clinical trials, although it does not cause acute liver toxicity or other specific forms of severe liver damage. Besides its weak antiviral activity against SARS-CoV-2, with a notable inhibition rate of 0.3% at 10 µM concentrations for 48 hours in Caco-2 cells and varied inhibition percentages in VERO-6 cells and 3CL-Pro protease assays, the compound also demonstrates potential inhibition of HDAC6, with enzymatic assay inhibition percentages of 17.77% and 12.71% using different substrates.
Moreover, Carbocisteine shows significant binding affinities and modulatory activities toward various neurotransmitter receptors and enzymes. This includes binding to ADRB1, ADRB2, SLC6A3, CHRNA4, HTR2C, DRD2, ADORA1, ADORA3, among others, and displaying agonistic activity at OPRM1 and DRD1 receptors, while acting antagonistically at CHRM2, HTR1A, ADRA1A, NR1I2, HTR2A, HTR2B, CNR1, rat Ar receptors, and inhibiting enzymes like PDE4D, PDE3A, MAOA, and Ptgs1.
These interactions suggest that Carbocisteine has potential bioactivity related to neurotransmitter modulation, enzyme inhibition, and antiviral effects, warranting further research into its pharmacological applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Carbocisteine (Mucodyne) is commonly used as an anti-infective nasal spray with mucolytic and expectorant effects. |
| Synonyms | S-Carboxymethyl-L-cysteine, Mucodyne, Carbocysteine, Broncodeterge |
| Molecular Weight | 179.19 |
| Formula | C5H9NO4S |
| Cas No. | 2387-59-9 |
| Smiles | N[C@@H](CSCC(O)=O)C(O)=O |
| Relative Density. | 1.514 g/cm3 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble)  H2O: 1 mg/mL (5.58 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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