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Chlorantraniliprole

Catalog No. T60127 CAS 500008-45-7

Synonyms: Rynaxypyr, Chlorantranilipole, Rynaxpyr

Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).

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Chlorantraniliprole, CAS 500008-45-7

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 68.00
50 mg	In stock	$ 105.00
100 mg	In stock	$ 155.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 97.04%

Biological Description

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Storage & Solubility Information

Description	Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).
In vitro	Chlorantraniliprole potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor. Chlorantraniliprole is ∼300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM)[1].
In vivo	Chlorantraniliprole exhibits low acute toxicity in mammals, with rats demonstrating an acute oral LD50 exceeding 5000 mg/kg. Additionally, it shows minimal to no toxicity in 90-day studies, even when administered at doses up to 1500 mg/kg/day[1].

Synonyms	Rynaxypyr, Chlorantranilipole, Rynaxpyr
Molecular Weight	483.15
Formula	C18H14BrCl2N5O2
CAS No.	500008-45-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56.7mg/mL (117.4mM)

References and Literature

1. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279.

Citations

1. Li B J, Wang K K, Yu Y, et al.PxRdl2 dsRNA increased the insecticidal activities of GABAR-targeting compounds against Plutella xylostella.Pesticide Biochemistry and Physiology.2023: 105548.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Chlorantraniliprole 500008-45-7 Others Rynaxypyr Chlorantranilipole Rynaxpyr inhibitor inhibit

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