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Odesivimab
(Synonyms: REGN-3471, REGN3471) Copy Product Info
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Synonyms: REGN-3471, REGN3471
Catalog No. T77105 Copy Product Info
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Odesivimab (REGN-3471) is a humanized monoclonal antibody that specifically targets the Ebola virus glycoprotein (GP). Odesivimab binds to the FcγRIIIa receptor on the surface of immune effector cells via its Fc region, inducing antibody-dependent cellular immunity (ADCI) to eliminate infected cells or viral particles, thereby exerting an antiviral effect. Odesivimab has a Kd value of 7.74 nM for the extracellular domain of the Ebola virus glycoprotein from the recombinant Makona strain.
Cas No. 2135632-30-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | - | In Stock | |
| 5 mg | $516 | - | In Stock | |
| 10 mg | $790 | - | In Stock | |
| 25 mg | $1,220 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.64% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Odesivimab (REGN-3471) is a humanized monoclonal antibody that specifically targets the Ebola virus glycoprotein (GP). Odesivimab binds to the FcγRIIIa receptor on the surface of immune effector cells via its Fc region, inducing antibody-dependent cellular immunity (ADCI) to eliminate infected cells or viral particles, thereby exerting an antiviral effect. Odesivimab has a Kd value of 7.74 nM for the extracellular domain of the Ebola virus glycoprotein from the recombinant Makona strain. |
| In vitro | Odesivimab, Atoltivimab and Maftivimab can be combined to form REGN-EB3 with an IC50 value of 0.39 nM, which can be used for Ebola virus research. Odesivimab showed specific binding to soluble viral glycoprotein. [1] |
| In vivo | Odesivimab with Atoltivimab and Maftivimab (REGN-3471, 50 mg/kg) were protective against Ebola virus infected rhesus monkey models. [1] |
| Synonyms | REGN-3471, REGN3471 |
| Reactivity | Virus |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Zaire Ebola virus |
| Molecular Weight | 146.16 kDa |
| Cas No. | 2135632-30-1 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Odesivimab chemical structure | Odesivimab in vivo | Odesivimab in vitro | Odesivimab molecular weight
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