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DKK1 Protein, Human, Recombinant
(Synonyms: DKK-1, Dickkopf-1) Copy Product InfoSynonyms: DKK-1, Dickkopf-1
Catalog No. TMPS-00020 Copy Product Info
DKK1 Protein, Human, Recombinant is expressed in HEK293 Cells. The accession number is O94907.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | Inquiry | 7-10 days | 7-10 days | |
| 50 µg | Inquiry | 7-10 days | 7-10 days | |
| 1 mg | Inquiry | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | ED 50 < 4.0 µg/ml, measured by its ability to inhibit Wnt3a induced alkaline phosphatase production by C3H10T1/2 cells. |
| Description | DKK1 Protein, Human, Recombinant is expressed in HEK293 Cells. The accession number is O94907. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | Tag Free |
| Accession Number | O94907 |
| Construction | Thr32-His266 |
| Protein Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 0.2 EU/μg of protein as determined by the LAL method. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | DKK-1, Dickkopf-1 |
| Research Background | Dickkopf related protein 1 (DKK-1) is a chemokine that belongs to the DKK protein family, which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbate in vitro. DKK-1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 not only functions as a head inducer during development, but also regulates joint remodeling and bone formation, which indicate sits role in the pathogenesis of rheumatoid arthritis and multiple myeloma. |
| Molecular Weight | 38~40 kDa (Reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
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Related Tags: DKK1 Protein, Human, Recombinant chemical structure | DKK1 Protein, Human, Recombinant molecular weight
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