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P2Y2R/GPR17 antagonist 1

Name: P2Y2R/GPR17 antagonist 1
Brand: TargetMol
SKU: T62420
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T62420 Copy Product Info

Purity: 98.42%

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P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual antagonist with an IC50 of 3.17 μM for P2Y2R and 1.67 μM for GPR17.

P2Y2R/GPR17 antagonist 1

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Catalog No. T62420

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual antagonist with an IC50 of 3.17 μM for P2Y2R and 1.67 μM for GPR17.

Cas No. 2395016-49-4

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Pack Size	Price	USA Stock	Global Stock
5 mg	$31	In Stock	In Stock
10 mg	$44	In Stock	In Stock
25 mg	$89	In Stock	In Stock
50 mg	$152	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.42%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

P2Y2R/GPR17 antagonist 1 AI Summary

P2Y2R/GPR17 antagonist 1 displays antagonist activity at multiple human receptors with varying efficacies. Specifically, it shows an IC50 value of 5780.0 nM against the human P2Y2 receptor, and it inhibits ATP-induced intracellular calcium influx by 54.0% at a concentration of 10 µM at the human P2X2 receptor. For the human GPR17 receptor, it presents an IC50 value of 1670.0 nM and achieves 72.0% inhibition of ATP-induced intracellular calcium influx at 10 µM. The compound has low drug metabolism, with just 1.4% metabolized in a pH 9 MeOH/water solution. In mouse liver microsomes at 1 µM, it has a half-life (T1/2) of 0.6967 hours and an intrinsic clearance (CLH) of 33.2 µL/min..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual antagonist with an IC50 of 3.17 μM for P2Y2R and 1.67 μM for GPR17.

Chemical Properties

Molecular Weight	432.83
Formula	C₁₉H₁₃ClN₂O₆S
Cas No.	2395016-49-4
Smiles	[O-][N+](=O)c1cccc(OS(=O)(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (259.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3104 mL	11.5519 mL	23.1038 mL	115.5188 mL
5 mM	0.4621 mL	2.3104 mL	4.6208 mL	23.1038 mL
10 mM	0.2310 mL	1.1552 mL	2.3104 mL	11.5519 mL
20 mM	0.1155 mL	0.5776 mL	1.1552 mL	5.7759 mL
50 mM	0.0462 mL	0.2310 mL	0.4621 mL	2.3104 mL
100 mM	0.0231 mL	0.1155 mL	0.2310 mL	1.1552 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc