Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATIC-IN-1 (compound 14) serves as an inhibitor specifically aimed at the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), with a K i of 685 nM. This dimerization is essential for the enzyme's aminoimidazole carboxamide ribonucleotide (AICAR) transformylase function. Furthermore, ATIC-IN-1 demonstrates anti-tumor properties by diminishing both cell proliferation and cell division rates [1].
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Description | ATIC-IN-1 (compound 14) serves as an inhibitor specifically aimed at the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), with a K i of 685 nM. This dimerization is essential for the enzyme's aminoimidazole carboxamide ribonucleotide (AICAR) transformylase function. Furthermore, ATIC-IN-1 demonstrates anti-tumor properties by diminishing both cell proliferation and cell division rates [1]. |
In vitro | ATIC-IN-1 (10 μM, 50 μM) is a specific inhibitor that exhibits a nonspecific aggregation mechanism, both in the presence and absence of BSA at concentrations of 1 mg/mL and 10 mg/mL [1]. |
Molecular Weight | 463.53 |
Formula | C21H33N7O5 |
CAS No. | 1402453-15-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ATIC-IN-1 1402453-15-9 inhibitor inhibit