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ARV-393

🥰Excellent
Catalog No. T84316Cas No. 2851885-95-3
Alias ARV393

ARV-393 is a PROTAC degrader targeting BCL6 with the advantage of being highly potent and orally available.ARV-393 recruits BCL6 and E3 ligase cerebellum to rapidly degrade BCL6 through the cell's natural ubiquitin proteasome system for the treatment of diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL).

ARV-393

ARV-393

🥰Excellent
Purity: 99.96%
Catalog No. T84316Alias ARV393Cas No. 2851885-95-3
ARV-393 is a PROTAC degrader targeting BCL6 with the advantage of being highly potent and orally available.ARV-393 recruits BCL6 and E3 ligase cerebellum to rapidly degrade BCL6 through the cell's natural ubiquitin proteasome system for the treatment of diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL).
Pack SizePriceAvailabilityQuantity
1 mg$223 In Stock
5 mg$562 In Stock
10 mg$892 In Stock
25 mg$1,820 In Stock
50 mg$2,830 In Stock
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Purity:99.96%
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Product Introduction

Bioactivity
Description
ARV-393 is a PROTAC degrader targeting BCL6 with the advantage of being highly potent and orally available.ARV-393 recruits BCL6 and E3 ligase cerebellum to rapidly degrade BCL6 through the cell's natural ubiquitin proteasome system for the treatment of diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL).
In vitro
ARV-393 demonstrated potent activity in multiple diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) cell lines, with both DC₅₀ and GI₅₀ values < 1 nM [1].
In vivo
In xenograft models, mice were orally administered ARV-393 (3, 10, 30 mg/kg; once daily; for 23 days) to evaluate its in vivo antitumor activity in lymphoma. ARV-393 significantly inhibited tumor growth. [2]
AliasARV393
Chemical Properties
Molecular Weight898.42
FormulaC46H53ClFN9O7
Cas No.2851885-95-3
SmilesFC1=C2C(C(=O)N(C2)C3C(=O)NC(=O)CC3)=CC=C1C4CCN(CC4)[C@@H]5C[C@@H](OC6CCN(CC6)C=7N=C(NC=8C=C9C(=CC8)N(C(C)C)C(=O)C(OCC(NC)=O)=C9)C(Cl)=CN7)C5
Relative Density.1.45 g/cm3 at 20℃ (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 8.00 mg/mL (8.90 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1131 mL5.5653 mL11.1307 mL55.6533 mL
5 mM0.2226 mL1.1131 mL2.2261 mL11.1307 mL

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