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Anti-DNM1L Polyclonal Antibody
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Catalog No. TMAB-00560
Alias Dynamin-related protein 1, Dynamin-like protein IV (HdynIV), Dynamin-like protein 4, Dynamin-like protein, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less (Dymple), DRP1, Dnm1p/Vps1p-like protein (DVLP), DNM1L, DLP1
Anti-DNM1L Polyclonal Antibody is a Rabbit antibody targeting DNM1L. Anti-DNM1L Polyclonal Antibody can be used in WB.
Anti-DNM1L Polyclonal Antibody
Anti-DNM1L Polyclonal Antibody
😃Good
Catalog No. TMAB-00560Alias Dynamin-related protein 1, Dynamin-like protein IV (HdynIV), Dynamin-like protein 4, Dynamin-like protein, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less (Dymple), DRP1, Dnm1p/Vps1p-like protein (DVLP), DNM1L, DLP1
Anti-DNM1L Polyclonal Antibody is a Rabbit antibody targeting DNM1L. Anti-DNM1L Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-DNM1L Polyclonal Antibody is a Rabbit antibody targeting DNM1L. Anti-DNM1L Polyclonal Antibody can be used in WB. |
| Synonyms | Dynamin-related protein 1, Dynamin-like protein IV (HdynIV), Dynamin-like protein 4, Dynamin-like protein, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less (Dymple), DRP1, Dnm1p/Vps1p-like protein (DVLP), DNM1L, DLP1 |
| Ig Type | IgG |
| Reactivity | Mouse |
| Verified Activity | Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Cerebellum tissue lysates Primary: Anti-DNM1L (TMAB-00560) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 81 kDa Observed band size: 75 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Note=Mainly cytosolic. Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. |
| Tissue Specificity | Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in b |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human DNM1L |
| Antigen Species | Human |
| Gene Name | DNM1L |
| Gene ID | |
| Protein Name | Dynamin-1-like protein |
| Uniprot ID | |
| Biology Area | Metabolism,Mitochondrial,Mitochondrial,Apoptosis,Mitochondrial markers,Neurodegenerative disease,Parkinson's disease,Mitochondrial |
| Function | Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. Required for programmed necrosis execution. May be involved in vesicle transport. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed. |
| Molecular Weight | Theoretical: 81 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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