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D-chiro-Inositol

Name: D-chiro-Inositol
Brand: TargetMol
SKU: T5915
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5915Cas No. 643-12-9

Alias D-(+)-CHIRO-INOSITOL

D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) is an epimer of myo-inositol that is found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity.

D-chiro-Inositol

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Purity: 99.76%

Catalog No. T5915Alias D-(+)-CHIRO-INOSITOLCas No. 643-12-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

D-chiro-Inositol AI Summary

D-chiro-Inositol exhibits diverse bioactivities with significant inhibitory and inductive properties. It functions as an inhibitor of the malarial parasite plastid with a potency of 7375.3 nM over a 96-hour incubation period and as an inhibitor of Polymerase Iota with a potency of 631.0 nM in a confirmatory assay. Additionally, it induces DNA re-replication in SW480 colon adenocarcinoma cells, achieving a potency of 231.1 nM in a high throughput screen assay. Moreover, D-chiro-Inositol significantly inhibits Baker's yeast Alpha-glucosidase-1 with an IC50 value of 1256100.0 nM, yet exhibits less than 30.0% inhibition of rat intestinal alpha-glucosidase maltase and sucrase when tested with maltose and sucrose, respectively. Furthermore, it induces glucose uptake in differentiated mouse 3T3L1 cells, increasing the uptake by 1.4-fold at 200 µM after 60 minutes and displaying 64.0% of the activity relative to insulin..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) is an epimer of myo-inositol that is found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity.
Synonyms	D-(+)-CHIRO-INOSITOL

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	643-12-9
Smiles	O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	2.038 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 75 mg/mL (416.3 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc