This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Antibacterial agent 141
Catalog No. T78976 CAS
2930013-56-0
Compound B14 (Antibacterial agent 141) exhibits antibacterial activity against the plant pathogens Xoo, Xac, Psa, and Cmm, with an EC50 value of 1.28 μM. It functions by inhibiting cell membrane formation and altering cell permeability.
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
Compound B14 (Antibacterial agent 141) exhibits antibacterial activity against the plant pathogens Xoo, Xac, Psa, and Cmm, with an EC50 value of 1.28 μM. It functions by inhibiting cell membrane formation and altering cell permeability.
In vitro
Antibacterial agent 141 significantly induces cell membrane rupture in Xoo bacteria [1]. It increases membrane permeability in a concentration-dependent manner within Xoo bacteria [1], and disrupts the surface of the bacterial cell membrane [1]. At concentrations of 3.2 and 6.4 μM, the agent notably reduces the expression of ACC, ACP, and Fab family genes in Xoo bacteria [1]. Additionally, it significantly inhibits biofilm formation of Xoo with increasing concentrations [1], while exhibiting low cytotoxicity towards HepG2 and HK-2 cells [1]. At concentrations ranging from 0.64 to 5.12 μM over 3 to 30 hours, it markedly suppresses the growth of Xoo bacteria [1].
In vivo
Antibacterial agent 141 at a concentration of 200 μg/mL, administered as a single dose over a period of 7 days, exhibited treatment and preventive activity against bacterial blight of 4.64% and 43.33%, respectively [1].
Molecular Weight
414.93
Formula
C23H27ClN2O3
CAS No.
2930013-56-0
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.