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Anti-CRABP2 Antibody (1B682)
😃Good
Catalog No. TMAY-01746
Alias CrabpII, Crabp-2, cellular retinoic acid binding protein 2, AI893628
Anti-CRABP2 Antibody (1B682) is a Rabbit antibody targeting CRABP2. Anti-CRABP2 Antibody (1B682) can be used in WB.
Anti-CRABP2 Antibody (1B682)
Anti-CRABP2 Antibody (1B682)
😃Good
Catalog No. TMAY-01746Alias CrabpII, Crabp-2, cellular retinoic acid binding protein 2, AI893628
Anti-CRABP2 Antibody (1B682) is a Rabbit antibody targeting CRABP2. Anti-CRABP2 Antibody (1B682) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB Reactivity: Human |
| Alias | CrabpII, Crabp-2, cellular retinoic acid binding protein 2, AI893628 |
| Ig Type | Rabbit IgG |
| Clone | 1B682 |
| Reactivity | Human |
| Verified Activity | Anti-CRABP2 rabbit monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell Lysate. -Lane B: MCF7 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:16 kDa. -Observed band size:14 kDa |
| Application | WB |
| Recommended Dose | WB: 1:500-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CRABP2 (rh CRABP2; TMPY-01549; NP_001869.1; Pro2-Glu138). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, CRABP-II and CRABP2, is a protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The predicted amino acid sequences of human CRABP1 and CRABP2 demonstrated a 99.3% and 93.5% identity to mouse CRABP1 and CRABP2, respectively. CRABP2 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Expression of CRABP2, but not CRABP1 mRNA, was markedly increased (greater than 15-fold) by retinoic acid treatment of fibroblasts cultured from human skin, whereas no significant induction of CRABP2 mRNA was observed in human lung fibroblasts. CRABP2 transports retinoic acid to the nucleus. It regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is necessary for elastin induction by All-trans retinoic acid (ATRA) in MRC-5 cells. It is expressed at low levels in emphysema fibroblasts. This alteration in the retinoic acid signalling pathway in lung fibroblasts may contribute to the defect of alveolar repair in human pulmonary emphysema. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CRABP2 protein (TMPY-01549) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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