PEDF Protein, Human, Recombinant

Name: PEDF Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPS-00148
Rating: 4.5 (1 reviews)

(Synonyms: SERPINF1, serpin family F member 1, Pigment epithelium-derived factor, PIG35, PEDF, OI6, OI12, EPC-1) Copy Product Info

Synonyms: SERPINF1, serpin family F member 1, Pigment epithelium-derived factor, PIG35, PEDF, OI6, OI12, EPC-1

Catalog No. TMPS-00148 Copy Product Info

PEDF Protein, Human, Recombinant is expressed in E. coli. The accession number is P36955.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$123	7-10 days	7-10 days
10 µg	$198	7-10 days	7-10 days
20 µg	$339	7-10 days	7-10 days
50 µg	$658	7-10 days	7-10 days
100 µg	$1,090	7-10 days	7-10 days
200 µg	$1,820	7-10 days	7-10 days
500 µg	$3,570	7-10 days	7-10 days
1 mg	$5,970	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Fully biologically active when compared to standard. The ED 50 as determined by its ability to enhance the adhesion of human Saos2 cells to bovine Collagen I coated plate is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 × 10 5 IU/mg.
Description	PEDF Protein, Human, Recombinant is expressed in E. coli. The accession number is P36955.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P36955
Construction	Gln20-Pro418
Protein Purity	> 97% as determined by SDS-PAGE; > 97% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Reconstitution	It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml.
Synonyms	SERPINF1, serpin family F member 1, Pigment epithelium-derived factor, PIG35, PEDF, OI6, OI12, EPC-1
Research Background	PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers.

Chemical Properties

Molecular Weight

44.4 kDa (Predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.