DFF45 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00483

DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.

DFF45 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00483

Pack Size	Price	Availability
5 μg	$72	7-10 days
10 μg	$116	7-10 days
20 μg	$176	7-10 days
50 μg	$310	7-10 days
100 μg	$532	7-10 days
200 μg	$919	7-10 days
500 μg	$1,900	7-10 days
1 mg	$2,730	7-10 days

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Product Information

Biological Activity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
Species	Human
Expression System	E. coli
Tag	N-6xHis
Accession Number	AAH07721.1
Synonyms	Inhibitor of CAD,ICAD,H13,DNA Fragmentation Factor Subunit α,DNA Fragmentation Factor Subunit Alpha,DNA Fragmentation Factor 45 kDa Subunit,DFFA,DFF-45,DFF45,DFF1
Amino Acid	Met1-Thr331
Construction	Met1-Thr331
Protein Purity	Greater than 85% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	40-50 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Shipping with blue ice.
Research Background	DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.