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PROTAC TYK2 degradation agent1

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Catalog No. T75026Cas No. 2921556-14-9

PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1].

PROTAC TYK2 degradation agent1

PROTAC TYK2 degradation agent1

😃Good
Catalog No. T75026Cas No. 2921556-14-9
PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1].
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1].
In vitro
PROTAC TYK2 degradation agent1 (degrader 37) selectively inhibits TYK2 protein levels at 1 µM for 6 hours and exhibits a DC50 value of 14 nM [1].
Chemical Properties
Molecular Weight1056.28
FormulaC55H69N13O7S
Cas No.2921556-14-9
SmilesO(C)C1=C(C=CC=C1NC=2C(C(NC)=O)=CN=C(NC3=CC=C(C(NCCCCCCCCCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)C=N3)C2)C=7N=CN(C)N7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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