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2B4/CD244 Protein, Mouse, Recombinant (aa 1-226, His)
(Synonyms: Nmrk, Cd244, 2b4) Copy Product InfoSynonyms: Nmrk, Cd244, 2b4
Catalog No. TMPY-07228 Copy Product Info
2B4/CD244 Protein, Mouse, Recombinant (aa 1-226, His) is expressed in HEK293 Cells. The accession number is Q07763-1.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $68 | 7-10 days | 7-10 days | |
| 10 µg | $109 | 7-10 days | 7-10 days | |
| 20 µg | $172 | 7-10 days | 7-10 days | |
| 50 µg | $343 | 7-10 days | 7-10 days | |
| 100 µg | $682 | 7-10 days | 7-10 days | |
| 200 µg | $987 | 7-10 days | 7-10 days | |
| 500 µg | $2,200 | 7-10 days | 7-10 days | |
| 1 mg | $4,500 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Recombinant Mouse 2B4/CD244 Protein (ECD, His Tag) at 2 μg/mL (100 μL/well) can bind Recombinant Mouse CD48/SLAMF2/BCM1 Protein (Fc Tag), the EC50 is 180-550 ng/mL. |
| Description | 2B4/CD244 Protein, Mouse, Recombinant (aa 1-226, His) is expressed in HEK293 Cells. The accession number is Q07763-1. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q07763-1 |
| Construction | A DNA sequence encoding the Mouse CD244 (NP_061199.2) (Met1-Pro226) was expressed with a polyhistidine tag at the C-terminus. |
| Protein Purity | ≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Please refer to the lot-specific COA. |
| Synonyms | Nmrk, Cd244, 2b4 |
| Research Background | The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Molecular Weight | 24.83 kDa (predicted); 48 kDa (reducing contition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: 2B4/CD244 Protein, Mouse, Recombinant (aa 1-226, His) chemical structure | 2B4/CD244 Protein, Mouse, Recombinant (aa 1-226, His) molecular weight
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