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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $85 | 5 days |
Description | K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1]. |
In vitro | PROTACs consist of two distinct ligands linked together, with one ligand targeting an E3 ubiquitin ligase and the other targeting a specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 789.96 |
Formula | C42H59N7O8 |
Cas No. | 2378261-85-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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