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JHU37160

Name: JHU37160
Brand: TargetMol
SKU: T9018
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9018Cas No. 2369979-68-8

Alias JHU 37160

JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

JHU37160

🥰Excellent

Purity: 99.87%

Catalog No. T9018Alias JHU 37160Cas No. 2369979-68-8

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$42	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$125	In Stock	In Stock
100 mg	$197	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
Targets&IC50	M3Dq DREADD (human):18.5 nM (EC50), M4Di DREADD (human):0.2 nM (EC50)
In vitro	JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells
In vivo	JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice
Synonyms	JHU 37160

Chemical Properties

Molecular Weight	358.84
Formula	C₁₉H₂₀ClFN₄
Cas No.	2369979-68-8
Smiles	CCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c(F)cccc12
Relative Density.	1.34 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 72 mg/mL (200.65 mM), Sonication is recommended.

DMSO: 72 mg/mL (200.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7868 mL	13.9338 mL	27.8676 mL	139.3379 mL
5 mM	0.5574 mL	2.7868 mL	5.5735 mL	27.8676 mL
10 mM	0.2787 mL	1.3934 mL	2.7868 mL	13.9338 mL
20 mM	0.1393 mL	0.6967 mL	1.3934 mL	6.9669 mL
50 mM	0.0557 mL	0.2787 mL	0.5574 mL	2.7868 mL
100 mM	0.0279 mL	0.1393 mL	0.2787 mL	1.3934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc