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SKLB-163

Name: SKLB-163
Brand: TargetMol
SKU: T26193
Price: 137 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26193Cas No. 1255099-06-9

Alias SKLB163

SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.

SKLB-163

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Purity: 99.23%

Catalog No. T26193Alias SKLB163Cas No. 1255099-06-9

SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$137	In Stock	In Stock
5 mg	$336	In Stock	In Stock
10 mg	$497	In Stock	In Stock
25 mg	$793	In Stock	In Stock
50 mg	$1,130	In Stock	In Stock
100 mg	$1,520	In Stock	In Stock
500 mg	$2,970	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$373	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.23%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

SKLB-163 AI Summary

SKLB-163 exhibits cytotoxic and antiproliferative activities against a variety of human cancer cell lines. As determined by MTT assay after 48 hours, it shows IC50 values ranging from 1100.0 nM to 6580.0 nM, indicating its potency in inhibiting cell growth by 50% across different cell types, including MCF7, HepG2, HeLa, A-375, SPCA1, SW620, and PC-3 cells. Lower IC50 values suggest higher potency in inhibiting the growth of these cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
Targets&IC50	A549 cells:4 μM, A431 cells:4.4 μM, HCT116 cells:1.3 μM, A375 cells:1.8 μM, BxPC-3 cells:6.6 μM
Synonyms	SKLB163

Chemical Properties

Molecular Weight	405.92
Formula	C₁₈H₁₆ClN₃O₂S₂
Cas No.	1255099-06-9
Smiles	S(CC(NCC1=CC=CC=C1)=O)C2=NC=3C(S2)=CC(NC(CCl)=O)=CC3
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (609.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4635 mL	12.3177 mL	24.6354 mL	123.1770 mL
5 mM	0.4927 mL	2.4635 mL	4.9271 mL	24.6354 mL
10 mM	0.2464 mL	1.2318 mL	2.4635 mL	12.3177 mL
20 mM	0.1232 mL	0.6159 mL	1.2318 mL	6.1588 mL
50 mM	0.0493 mL	0.2464 mL	0.4927 mL	2.4635 mL
100 mM	0.0246 mL	0.1232 mL	0.2464 mL	1.2318 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc