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Anti-JAK1 Antibody (4O967)
Catalog No. TMAC-02260 Copy Product Info
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Anti-JAK1 Antibody (4O967) is a Rabbit antibody targeting JAK1. Anti-JAK1 Antibody (4O967) can be used in FCM,IHC,WB.
Anti-JAK1 Antibody (4O967)
Copy Product Info🥰Excellent
Catalog No. TMAC-02260
Anti-JAK1 Antibody (4O967) is a Rabbit antibody targeting JAK1. Anti-JAK1 Antibody (4O967) can be used in FCM,IHC,WB.
Anti-JAK1 Antibody
(4O967)
(4O967)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $298 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-JAK1 Antibody (4O967) is a Rabbit antibody targeting JAK1. Anti-JAK1 Antibody (4O967) can be used in FCM,IHC,WB. |
| Ig Type | IgG |
| Clone | 4O967 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of JAK1 on Hela cell using anti-JAK1 antibody at 1/1,000 dilution. Positive control: Lane 1: PC-12, Lane 2: Jurkat, Lane 3: NIH-3T3. 2. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-JAK1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-JAK1 antibody. Counter stained with hematoxylin. 4. Flow cytometric analysis of SW480 cells with JAK1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).     |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at position 1022 and 1023 is believed to function in the activation of catalytic events. The canonical JAK-Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering JAK-Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for inflammatory therapies. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 133 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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