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ABC

The ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters often consist of multiple subunits, one or two of which are transmembrane proteins and one or two of which are membrane-associated AAA ATPases. The ATPase subunits utilize the energy of adenosine triphosphate (ATP) binding and hydrolysis to provide the energy needed for the translocation of substrates across membranes, either for uptake or for export of the substrate.

  • DIDS sodium salt
    T1897567483-13-0
    DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
    • $33
    In Stock
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  • Vismodegib
    T2590879085-55-9
    Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
    • $38
    In Stock
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    TargetMol | Citations Cited
  • Tepotinib hydrochloride(1 : x)
    T96011103508-80-0
    Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.
    • $148
    In Stock
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  • CCTA-1523
    T95871616271-41-0In house
    CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
    • $148
    In Stock
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  • Prazosin hydrochloride
    T105019237-84-4
    Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic piperazine derivative with hypotensive antiadrenergic properties, It is used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.
    • $50
    In Stock
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    TargetMol | Citations Cited
  • 5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
    TN712419056-75-8
    5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.
    • $195
    Backorder
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    TargetMol | Inhibitor Sale
  • Chlorpropamide
    T049094-20-2
    Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
    • $31
    In Stock
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    TargetMol | Inhibitor Sale
  • 6,8-Diprenylnaringenin
    TN315068236-11-3
    6,8-Diprenylnaringenin (Senegalensin) is a natural product from hop Humulus lupulus. 6,8-Diprenylnaringenin is a breast cancer resistance protein(BCRP) inhibitor with some estrogenicity.
    • $417
    Backorder
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  • Isosilybin A
    TN1804142796-21-2
    Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
    • $80
    In Stock
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  • Acridone
    T20003578-95-0
    Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.
    • $30
    In Stock
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  • Vigabatrin
    T012860643-86-9
    Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric acid.
    • $44
    In Stock
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  • Erythrodiol
    T8165545-48-2
    Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.
    • $51
    In Stock
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  • Glipizide
    T160329094-61-9
    Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
    • $40
    In Stock
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  • Novobiocin Sodium
    T09741476-53-5
    Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.
    • $42
    In Stock
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  • Fumitremorgin C
    T15355118974-02-0
    Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.
    • $530
    35 days
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  • Ko 143
    TQ0186461054-93-3
    Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).
    • $39
    In Stock
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  • Thiethylperazine
    T619151420-55-9
    Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice, is used to relieve vertigo, and can be used in studies of neurological diseases such as Alzheimer's disease and Parkinson's disease. Alzheimer's and Parkinson's diseases.
    • $46
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  • Probucol
    T025423288-49-5
    Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
    • $58
    In Stock
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  • Glafenine Hydrochloride
    T0055L65513-72-6
    Glafenine Hydrochloride is an anti-inflammatory agent.
    • $33
    In Stock
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  • Thiethylperazine dimaleate
    T170721179-69-7
    Thiethylperazine dimaleate (Thiethylperazine maleate) is an antagonist of the D2 receptor and H1 receptor. Thiethylperazine dimaleate is an activator of ABCC1 and possesses antimicrobial, anti-emetic, and antipsychotic effects.
    • $48
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  • MMAF sodium
    T161221799706-65-2
    MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
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