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Anti-Cyclin E Antibody (4I417) (Synonyms: cyclin E1, CycE1, AW538188)
Catalog No. TMAY-01314 Copy Product Info
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Anti-Cyclin E Antibody (4I417) is a Mouse antibody targeting Cyclin E. Anti-Cyclin E Antibody (4I417) can be used in IHC-P.
Anti-Cyclin E Antibody (4I417)
Copy Product Info🥰Excellent
Catalog No. TMAY-01314
Synonyms cyclin E1, CycE1, AW538188
Anti-Cyclin E Antibody (4I417) is a Mouse antibody targeting Cyclin E. Anti-Cyclin E Antibody (4I417) can be used in IHC-P.
Anti-Cyclin E Antibody
(4I417)
(4I417)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $198 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Cyclin E Antibody (4I417) is a Mouse antibody targeting Cyclin E. Anti-Cyclin E Antibody (4I417) can be used in IHC-P. |
| Synonyms | cyclin E1, CycE1, AW538188 |
| Ig Type | Mouse IgG1 |
| Clone | 4I417 |
| Reactivity | Human |
| Specificity | Human Cyclin E |
| Verified Activity | 1. Immunochemical staining of human CCNE1 in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing nucleus staining of cells. 2. Immunochemical staining of human CCNE1 in human ovarian cancer with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing nucleus staining of cells. 3. Immunochemical staining of human CCNE1 in human colon carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing nucleus staining of cells. |
| Application | |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CCNE1 / Cyclin-E1 (rh CCNE1 / Cyclin-E1; NP_001229.1Met1-Ala410). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CCNE1 / Cyclin-E1 protein |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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