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Anti-Cyclin E Antibody (4I417)
😃Good
Catalog No. TMAY-01314
Alias cyclin E1, CycE1, AW538188
Anti-Cyclin E Antibody (4I417) is a Mouse antibody targeting Cyclin E. Anti-Cyclin E Antibody (4I417) can be used in IHC-P.
Anti-Cyclin E Antibody (4I417)
Anti-Cyclin E Antibody (4I417)
😃Good
Catalog No. TMAY-01314Alias cyclin E1, CycE1, AW538188
Anti-Cyclin E Antibody (4I417) is a Mouse antibody targeting Cyclin E. Anti-Cyclin E Antibody (4I417) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | cyclin E1, CycE1, AW538188 |
| Ig Type | Mouse IgG1 |
| Clone | 4I417 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CCNE1 in human placenta with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing nucleus staining of cells. 2. Immunochemical staining of human CCNE1 in human ovarian cancer with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing nucleus staining of cells. 3. Immunochemical staining of human CCNE1 in human colon carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). The image showing nucleus staining of cells. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CCNE1 / Cyclin-E1 (rh CCNE1 / Cyclin-E1; NP_001229.1Met1-Ala410). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CCNE1 / Cyclin-E1 protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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