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TargetMol | Tags GPCR/G Protein
TargetMol | Tags Neuroscience

OX Receptor

The orexin receptor is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2).

  • Orexin B, rat, mouse Acetate
    TP1045L
    Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
    • $308
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  • DORA-22
    T55001088991-95-0
    DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
    • $133
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  • Daridorexant hydrochloride
    T677821792993-84-0
    Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.
    • $129
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  • OXA (17-33) acetate
    TP1973L
    OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
    • $488
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  • [Ala11,D-Leu15]-Orexin B acetate
    TP1975L
    [Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).
    • $524
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  • Orexin 2 Receptor Agonist
    T31771796565-52-0
    Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
    • $41
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  • IPSU
    T55031373765-19-5
    IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
    • $34
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  • MK-1064
    T37221207253-08-4
    MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).
    • $48
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  • Filorexant
    T160961088991-73-4
    Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
    • $48
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  • SB-408124
    T6658288150-92-5
    SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
    • $40
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  • SB-649868
    T5498380899-24-1
    SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
    • $48
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  • PF3274167
    T3347900510-03-4
    PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
    • $47
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  • SB-674042
    T16854483313-22-0
    SB-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50s of 3.76 nM and 531 nM, respectively.SB-674042 can be used for the treatment of depression.
    • $45
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  • ACT-462206
    T265591361321-96-1
    ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety.
    • $37
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  • Almorexant hydrochloride
    T6155913358-93-7
    Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
    • $70
    Backorder
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  • TCS 1102
    T2710916141-36-1
    TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
    • $57
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  • Seltorexant
    T12877L1293281-49-8
    Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R).
    • $31
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  • MK-3697
    T19131224846-01-8
    MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
    • $44
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  • YNT-185
    T392291804978-81-1
    YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
    • $60
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  • L-368,899 hydrochloride
    T11794160312-62-9
    L-368,899 hydrochloride is an orally available and selective nonpeptide oxytocin receptor (OXTR) antagonist for the prevention of preterm labor.L-368,899 hydrochloride prevents oxytocin-induced anti-anomalous pain and anti-nausea, and may be useful for the study of depression.
    • $113
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  • TCS-OX2-29
    T4965372523-75-6
    TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
    • $39
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  • SB-334867 free base
    T6140792173-99-0
    SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.
    • $32
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  • EMPA
    T11186680590-49-2
    EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively)
    • $47
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  • Almorexant
    T2613871224-64-5
    Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
    • $39
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