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(+)-SHIN1

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Catalog No. T12898Cas No. 2443966-90-1
Alias (R)-SHIN-1

(+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2).

(+)-SHIN1
Other Forms of (+)-SHIN1:

(+)-SHIN1

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Catalog No. T12898Alias (R)-SHIN-1Cas No. 2443966-90-1
(+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,4706-8 weeks6-8 weeks
50 mg$1,9206-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
(+)-SHIN1 ((+)-RZ-2994) is the active (+) enantiomer of SHIN1, which inhibits human serine hydroxymethyltransferase 1 and 2 (SHMT1/2).
In vitro
(+)-SHIN1 ((+)-RZ-2994) exhibits potent inhibition of cytosolic SHMT1, with IC50 values of less than 50 nM in SHMT2 deletion cells and 870 nM in HCT-116 cells, effectively blocking cell growth [1].
Synonyms(R)-SHIN-1
Chemical Properties
Molecular Weight400.47
FormulaC24H24N4O2
Cas No.2443966-90-1
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (249.71 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.24 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4971 mL12.4853 mL24.9707 mL124.8533 mL
5 mM0.4994 mL2.4971 mL4.9941 mL24.9707 mL
10 mM0.2497 mL1.2485 mL2.4971 mL12.4853 mL
20 mM0.1249 mL0.6243 mL1.2485 mL6.2427 mL
50 mM0.0499 mL0.2497 mL0.4994 mL2.4971 mL
100 mM0.0250 mL0.1249 mL0.2497 mL1.2485 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(+)-SHIN-1(+)SHIN1(+)-RZ-2994(+) SHIN1
Related Tags: buy (+)-SHIN1 | purchase (+)-SHIN1 | (+)-SHIN1 cost | order (+)-SHIN1 | (+)-SHIN1 chemical structure | (+)-SHIN1 in vitro | (+)-SHIN1 formula | (+)-SHIN1 molecular weight
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