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Anti-Complement factor H/CFH Antibody (5F716)
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Catalog No. TMAY-01106
Alias Sas-1, Sas1, NOM, Mud-1, complement factor H
Anti-Complement factor H/CFH Antibody (5F716) is a Mouse antibody targeting Complement factor H/CFH. Anti-Complement factor H/CFH Antibody (5F716) can be used in ELISA.
Anti-Complement factor H/CFH Antibody (5F716)
Anti-Complement factor H/CFH Antibody (5F716)
😃Good
Catalog No. TMAY-01106Alias Sas-1, Sas1, NOM, Mud-1, complement factor H
Anti-Complement factor H/CFH Antibody (5F716) is a Mouse antibody targeting Complement factor H/CFH. Anti-Complement factor H/CFH Antibody (5F716) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Complement factor H/CFH Antibody (5F716) is a Mouse antibody targeting Complement factor H/CFH. Anti-Complement factor H/CFH Antibody (5F716) can be used in ELISA. |
| Alias | Sas-1, Sas1, NOM, Mud-1, complement factor H |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5F716 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Complement Factor H / CFH (rh Complement Factor H / CFH; TMPY-01439; NP_000177.2; Ser 860-Arg 1231). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Complement Factor H / CFH Protein (TMPY-01439) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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