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Aderbasib

Name: Aderbasib
Brand: TargetMol
SKU: T40901
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T40901Cas No. 791828-58-5

Alias INCB7839, INCB007839, INCB 7839, INCB 007839

Aderbasib (INCB007839) is an orally active and potent ADAM10 and ADAM17 inhibitor with antitumor activity, used for studying cancer and cardiovascular diseases.

Aderbasib

🥰Excellent

Purity: 97.828%

Catalog No. T40901Alias INCB7839, INCB007839, INCB 7839, INCB 007839Cas No. 791828-58-5

Aderbasib (INCB007839) is an orally active and potent ADAM10 and ADAM17 inhibitor with antitumor activity, used for studying cancer and cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	-	In Stock
5 mg	$328	-	In Stock
10 mg	$538	-	In Stock
25 mg	$1,070	-	In Stock
50 mg	$1,720	-	In Stock
1 mL x 10 mM (in DMSO)	$363	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.828%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Aderbasib (INCB007839) is an orally active and potent ADAM10 and ADAM17 inhibitor with antitumor activity, used for studying cancer and cardiovascular diseases.
In vitro	Aderbasib inhibits the shedding of all EGFR ligands by inhibiting ADAM10 and ADAM17. Aderbasib significantly reduced soluble HB-EGF levels in tumor tissue. [1]
In vivo	Aderbasib (60 mg/kg/day, tube feeding) combined with EP (0.5 mg/kg, ip) or PEPDG278D (4 mg/kg, ip) inhibited the growth of HCT116 and HT29 tumors. [1]
Synonyms	INCB7839, INCB007839, INCB 7839, INCB 007839

Chemical Properties

Molecular Weight	416.47
Formula	C₂₁H₂₈N₄O₅
Cas No.	791828-58-5
Smiles	C(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCN(CC3)C4=CC=CC=C4)CC2
Relative Density.	1.38 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (192.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4011 mL	12.0057 mL	24.0113 mL	120.0567 mL
5 mM	0.4802 mL	2.4011 mL	4.8023 mL	24.0113 mL
10 mM	0.2401 mL	1.2006 mL	2.4011 mL	12.0057 mL
20 mM	0.1201 mL	0.6003 mL	1.2006 mL	6.0028 mL
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4011 mL
100 mM	0.0240 mL	0.1201 mL	0.2401 mL	1.2006 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc