Shopping Cart

Your shopping cart is currently empty

Aderbasib

Name: Aderbasib
Brand: TargetMol
SKU: T40901
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T40901Cas No. 791828-58-5

Alias INCB7839, INCB007839, INCB 7839, INCB 007839

Aderbasib (INCB007839) is an orally active and potent ADAM10 and ADAM17 inhibitor with antitumor activity, used for studying cancer and cardiovascular diseases.

Aderbasib

😃Good

Purity: 99.15%

Catalog No. T40901Alias INCB7839, INCB007839, INCB 7839, INCB 007839Cas No. 791828-58-5

Aderbasib (INCB007839) is an orally active and potent ADAM10 and ADAM17 inhibitor with antitumor activity, used for studying cancer and cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	-	In Stock
5 mg	$328	-	In Stock
10 mg	$538	-	In Stock
25 mg	$1,070	-	In Stock
50 mg	$1,720	-	In Stock
1 mL x 10 mM (in DMSO)	$363	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.15%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Aderbasib (INCB007839) is an orally active and potent ADAM10 and ADAM17 inhibitor with antitumor activity, used for studying cancer and cardiovascular diseases.
In vitro	Aderbasib inhibits the shedding of all EGFR ligands by inhibiting ADAM10 and ADAM17. Aderbasib significantly reduced soluble HB-EGF levels in tumor tissue. [1]
In vivo	Aderbasib (60 mg/kg/day, tube feeding) combined with EP (0.5 mg/kg, ip) or PEPDG278D (4 mg/kg, ip) inhibited the growth of HCT116 and HT29 tumors. [1]
Synonyms	INCB7839, INCB007839, INCB 7839, INCB 007839

Chemical Properties

Molecular Weight	416.47
Formula	C₂₁H₂₈N₄O₅
Cas No.	791828-58-5
Smiles	C(NO)(=O)[C@H]1CC2(CN(C(OC)=O)[C@@H]1C(=O)N3CCN(CC3)C4=CC=CC=C4)CC2
Relative Density.	1.38 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (192.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4011 mL	12.0057 mL	24.0113 mL	120.0567 mL
5 mM	0.4802 mL	2.4011 mL	4.8023 mL	24.0113 mL
10 mM	0.2401 mL	1.2006 mL	2.4011 mL	12.0057 mL
20 mM	0.1201 mL	0.6003 mL	1.2006 mL	6.0028 mL
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4011 mL
100 mM	0.0240 mL	0.1201 mL	0.2401 mL	1.2006 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc