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DL-Pyroglutamic acid

Name: DL-Pyroglutamic acid
Brand: TargetMol
SKU: T9371
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9371Cas No. 149-87-1

DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen.

DL-Pyroglutamic acid

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Purity: 99.88%

Catalog No. T9371Cas No. 149-87-1

DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:solid

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

DL-Pyroglutamic acid AI Summary

DL-Pyroglutamic acid demonstrates inhibition of pyroglutamylaminopeptidase at different doses, relative to Pyrrolidin-2-one-CO-Gly-Ile and 2-Oxo-hexahydro-pyrimidine-4-carboxylic acid, affecting hydrolysis rates. Additionally, it shows bioactivities as an inhibitor in various assays: it inhibits AmpC Beta-Lactamase with a potency of 39810.7 nM, Nrf2 signaling with a potency of 25929.0 nM, Chronic Active B-Cell Receptor Signaling with a potency of 4466.8 nM, and the malarial parasite plastid with potencies of 6573.3 nM in a 96-hour assay and 58.6 nM in a 48-hour assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

DL-Pyroglutamic acid exhibited a strong inactivating effect on hepatitis B surface antigen.

Chemical Properties

Molecular Weight	129.11
Formula	C₅H₇NO₃
Cas No.	149-87-1
Smiles	C(O)(=O)C1NC(=O)CC1
Relative Density.	1.38 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (387.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.7453 mL	38.7267 mL	77.4533 mL	387.2667 mL
5 mM	1.5491 mL	7.7453 mL	15.4907 mL	77.4533 mL
10 mM	0.7745 mL	3.8727 mL	7.7453 mL	38.7267 mL
20 mM	0.3873 mL	1.9363 mL	3.8727 mL	19.3633 mL
50 mM	0.1549 mL	0.7745 mL	1.5491 mL	7.7453 mL
100 mM	0.0775 mL	0.3873 mL	0.7745 mL	3.8727 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc