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4-amino-1,8-Naphthalimide
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Catalog No. T21524Cas No. 1742-95-6
4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM
4-amino-1,8-Naphthalimide
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Purity: 95.13%
Catalog No. T21524Cas No. 1742-95-6
4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $53 | In Stock | In Stock | |
| 50 mg | $88 | In Stock | In Stock | |
| 100 mg | $143 | In Stock | In Stock | |
| 200 mg | $212 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:95.13%
Appearance:solid
Color:Yellow
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Product Introduction
4-amino-1,8-Naphthalimide AI Summary
4-amino-1,8-Naphthalimide is a multifunctional bioactive molecule with notable inhibitory activities across several biological assays. It is a potent poly(ADP-ribose)-polymerase (PARP) inhibitor with an IC50 value of 180.0 nM against lung carcinoma A549 cells and exhibits stronger PARP1 inhibition with an IC50 value of 26.0 nM in human PC12 cells. Additionally, it sensitizes cisplatin-induced cytotoxicity in BxPC3 and U2OS cells by 1.6-fold and 2.3-fold, respectively.
The compound also demonstrates antiplasmodial activity against Plasmodium falciparum 3D7 with an IC50 value of 7943.28 nM. Further bioactivity includes inhibiting Menin-MLL, BRCT-Phosphoprotein interactions, APE1, RECQ1, Caspases, Tau fibril formation, and Tyrosyl-DNA Phosphodiesterase, among other proteins. It inhibits TEM-1 and NDM-1 enzymes, showing an Imax of 131.0% and an IC50 of 5200.0 nM for TEM-1 and an Imax of 409.0% and an IC50 of 700.0 nM for NDM-1. The compound displaces [3H]rosiglitazone in assays involving MitoNEET with an IC50 of 264000.0 nM and a Ki value of 11282.0 nM.
Moreover, 4-amino-1,8-Naphthalimide is active against PARP in Chinese hamster VC8 cells with a BRCA2 mutation, with an IC50 of 2590.0 nM and shows a selectivity ratio of 77.0 favoring wild type BRCA2 over BRCA2 mutant cells. This broad spectrum of activities indicates its potential in various therapeutic applications, including cancer treatment, antimicrobial therapy, and possibly in modulating mitochondrial functions..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM |
| Molecular Weight | 212.2 |
| Formula | C12H8N2O2 |
| Cas No. | 1742-95-6 |
| Smiles | Nc1ccc2C(=O)NC(=O)c3cccc1c23 |
| Relative Density. | 2.665 g/cm3. Temperature:20 °C. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.6 mg/mL (16.97 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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