Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1]. |
In vitro | SCD1-IN-1 (compound I, 6 days) effectively suppresses the SCD1 enzyme activity in intact human cells, exhibiting an inhibitory concentration (IC 50) of 6.8 nM [1]. |
In vivo | SCD1-IN-1 (compound I, 1.5% w/v, 25 μL), when applied to the ventral surfaces of both ears of the hamster ear model [1] at a dosage of 1.5% in a vehicle of propylene glycol/transcutanol/ethanol (20/20/60, w/v, 25 μL), twice daily for two weeks, significantly reduces cholesterol ester (CE) and wax ester (WE) production. Specifically, it results in a 62% decrease in CE and an 82% reduction in WE, serving as a biomarker for sebum production, and diminishes sebaceous gland size. This demonstrates its efficacy in modifying lipid synthesis within this animal model. |
Molecular Weight | 395.37 |
Formula | C20H20F3NO4 |
CAS No. | 1111078-63-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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SCD1-IN-1 1111078-63-7 inhibitor inhibit