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NoxA1ds acetate(1435893-78-9 free base)

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Catalog No. TP1886L1

NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

NoxA1ds acetate(1435893-78-9 free base)
Other Forms of NoxA1ds acetate(1435893-78-9 free base):

NoxA1ds acetate(1435893-78-9 free base)

🥰Excellent
Purity: 96.92%
Catalog No. TP1886L1
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
Pack SizePriceAvailabilityQuantity
1 mg$133In Stock
5 mg$302In Stock
10 mg$453In Stock
25 mg$748In Stock
50 mg$1,050In Stock
100 mg$1,420In Stock
500 mg$2,830In Stock
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Purity:96.92%
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COA HPLC MS

Product Introduction

Bioactivity
Description
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
Targets&IC50
NOX1:20 nM
Chemical Properties
Molecular Weight1185.35
FormulaC52H92N14O17
SmilesC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)N.CC(=O)O
Relative Density.no data available
SequenceH-Glu-Pro-Val-Asp-Ala-Leu-Gly-Lys-Ala-Lys-Val-NH2.CH3CO2H
Sequence ShortEPVDALGKAKV
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 10 mM, Sonication is recommended.
DMSO: Insoluble
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.8436 mL4.2182 mL8.4363 mL42.1816 mL
5 mM0.1687 mL0.8436 mL1.6873 mL8.4363 mL
10 mM0.0844 mL0.4218 mL0.8436 mL4.2182 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

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