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SN-011

Name: SN-011
Brand: TargetMol
SKU: T9137
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9137Cas No. 2249435-90-1

Alias GUN35901, [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-

SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.

SN-011

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Purity: 98.1%

Catalog No. T9137Alias GUN35901, [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-Cas No. 2249435-90-1

SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.

Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$70	In Stock
5 mg	$116	In Stock
10 mg	$178	In Stock
25 mg	$297	In Stock
50 mg	$453	In Stock
100 mg	$667	In Stock
1 mL x 10 mM (in DMSO)	$128	In Stock

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Batch Information

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Purity:98.1%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
Targets&IC50	STING signaling:76 nM (IC50)
Synonyms	GUN35901, [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-

Chemical Properties

Molecular Weight	462.49
Formula	C₂₅H₁₉FN₂O₄S
Cas No.	2249435-90-1
Smiles	Oc1ccc(NC(=O)c2ccc(cc2)-c2ccccc2)cc1NS(=O)(=O)c1ccc(F)cc1
Relative Density.	1.421 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (129.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1622 mL	10.8110 mL	21.6221 mL	108.1104 mL
5 mM	0.4324 mL	2.1622 mL	4.3244 mL	21.6221 mL
10 mM	0.2162 mL	1.0811 mL	2.1622 mL	10.8110 mL
20 mM	0.1081 mL	0.5406 mL	1.0811 mL	5.4055 mL
50 mM	0.0432 mL	0.2162 mL	0.4324 mL	2.1622 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc