Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for applications as a HIF-1α stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1].
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Description | VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for applications as a HIF-1α stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1]. |
Molecular Weight | 544.68 |
Formula | C28H37FN4O4S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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VHL-IN-1 Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase inhibitor inhibit