Shopping Cart

Your shopping cart is currently empty

Aceclofenac

Name: Aceclofenac
Brand: TargetMol
SKU: T1421
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T1421Cas No. 89796-99-6

Alias Preservex, Airtal

Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.

Aceclofenac

Copy Product Info

😃Good

Purity: 99.87%

Catalog No. T1421Alias Preservex, AirtalCas No. 89796-99-6

Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$30	-	In Stock
5 g	$43	-	In Stock
10 g	$61	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.87%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Aceclofenac AI Summary

Aceclofenac exhibits a wide range of bioactivities and inhibitory effects across various targets. It is a potent inhibitor of Lamin A splicing (44.7 nM), and also inhibits the MLL CXXC domain-DNA interaction (3548.1 nM), Ubiquitin-specific Protease USP2a (3162.3 nM), Cytochrome P450 2C9 (1584.9 nM), and Human Apurinic/apyrimidinic Endonuclease 1 (631.0 nM). It shows efficacy against malarial parasite plastid with potencies of 2.9 nM and 4.1 nM. Additionally, it demonstrates DNA re-replication induction in SW480 colon adenocarcinoma cells (366.3 nM). The compound shows significant liver toxicity, with elevated serum activities of ALT, AST, and alkaline phosphatase, indicating hepatotoxicity. It also affects kidney function and electrolyte balance, hinting at potential nephrotoxic effects. Aceclofenac has a low apparent permeability across the human Caco2 cell membrane (logPapp value of -4.41) and displays varying solubility levels in different conditions, with higher solubility in simulated gastric fluid. Aceclofenac also has antiviral properties, showing moderate activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Vero-6 and Caco-2 cells, and demonstrating a moderate inhibitory effect on the SARS-CoV-2 3CL-Pro protease (32.95% inhibition at 20µM). Moreover, it exhibits anti-inflammatory activity by inhibiting heat-induced egg albumin denaturation at 31.25 µg/ml. The compound inhibits human bile salt export pump (BSEP) (IC50 of 105,000.0 nM) and multidrug resistance-associated proteins MRP3 and MRP4. It binds to Transthyretin (TTR) in human plasma (IC50 of 170,000.0 nM and Kd of 1,200.0 nM). Other activities include inhibition of Aldose Reductase (IC50 of 1288.0 nM) and Protein Serine/Threonine Kinase ERK2 (IC50 of 5927.0 nM), and moderate inhibitory activity on the human HDAC6 enzyme..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.
Targets&IC50	COX-1:7.3 μM (IC50), COX-2:3 μM (IC50)
Synonyms	Preservex, Airtal

Chemical Properties

Molecular Weight	354.18
Formula	C₁₆H₁₃Cl₂NO₄
Cas No.	89796-99-6
Smiles	N(C1=C(CC(OCC(O)=O)=O)C=CC=C1)C2=C(Cl)C=CC=C2Cl
Relative Density.	1.455 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (155.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8234 mL	14.1171 mL	28.2342 mL	141.1712 mL
5 mM	0.5647 mL	2.8234 mL	5.6468 mL	28.2342 mL
10 mM	0.2823 mL	1.4117 mL	2.8234 mL	14.1171 mL
20 mM	0.1412 mL	0.7059 mL	1.4117 mL	7.0586 mL
50 mM	0.0565 mL	0.2823 mL	0.5647 mL	2.8234 mL
100 mM	0.0282 mL	0.1412 mL	0.2823 mL	1.4117 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc