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2-Deoxy-D-glucose

Name: 2-Deoxy-D-glucose
Brand: TargetMol
SKU: T6742
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6742Cas No. 154-17-6

Alias NSC 15193, D-Arabino-2-deoxyhexose, Ba 2758, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexose

2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.

2-Deoxy-D-glucose

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Purity: 99.91%

Catalog No. T6742Alias NSC 15193, D-Arabino-2-deoxyhexose, Ba 2758, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexoseCas No. 154-17-6

2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$33	In Stock	In Stock
1 g	$45	In Stock	In Stock
5 g	$113	-	In Stock
10 g	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
Targets&IC50	B-CPAP cells viability:1.154 mM, Caenorhabditis elegans growth:19.5 mM, THP-1 cells viability:16.14 mM, HL-60 cells viability:15.55 mM, Kasumi-1 cells viability:0.92 mM, NB4 cells viability:5.75 mM, EtHK enzyme:5.66 mM (Km)
In vitro	METHODS: Pancreatic cancer cells MIA PaCa2, BxPC-3, ASPC-1 and ovarian cancer cells OVCAR-3, HEY, SK-OV-3 were treated with 2-Deoxy-D-glucose (0.01-100 mM) for 48 h. Cell proliferation was detected using MTT. RESULTS: 2-Deoxy-D-glucose showed significant antiproliferative activity against tumor cells with IC50 values ranging from 1.45-13.34 mM. [1] METHODS: Triple-negative breast cancer cells Hs578T were treated with 2-Deoxy-D-glucose (15 mM) for 24 days, and cell motility was detected by Migration assay and Invasion assay. RESULTS: 2-Deoxy-D-glucose inhibited the migration and invasion of Hs578T cells. [2]
In vivo	METHODS: To study the effects on leukocyte subpopulation distribution and function, 2-Deoxy-D-glucose (500-1500 mg/kg) was injected intraperitoneally into BDF1 mice once or thrice. RESULTS: Blood glucose concentrations increased in a dose-dependent manner in mice injected with up to 1500 mg/kg of 2-Deoxy-D-glucose. Corticosterone levels, leukocyte counts in the spleen, and CD3+ cells in the thymus increased after one or three injections of 2-Deoxy-D-glucose up to 1500 mg/kg. 2-Deoxy-D-glucose administration induced dose-dependent changes in thymic and splenic cell distribution and function. [3] METHODS: To test the antitumor activity in vivo, 2-Deoxy-D-glucose (1000 mg/kg) was administered intraperitoneally to C57BL/6 mice bearing melanoma B16 once daily for eight days. RESULTS: 2-Deoxy-D-glucose significantly inhibited tumor growth, and TAMs showed a significant decrease in Arg, Fizz, CD206 and Vegf expression after 2-Deoxy-D-glucose treatment. [4]
Cell Research	2×103 H460 or H157 cells are seeded in 96-well cell culture plates. Cells are treated with 5 mM 2-DG only, 5 or 10 μM IGF1R inhibitor II only, or a combination of 2-DG and IGF1R inhibitor II. Cell growth inhibition is determined after 48 h by the CellTiter 96® AQueous nonradioactive cell proliferation assay. (Only for Reference)
Synonyms	NSC 15193, D-Arabino-2-deoxyhexose, Ba 2758, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexose

Chemical Properties

Molecular Weight	164.16
Formula	C₆H₁₂O₅
Cas No.	154-17-6
Smiles	OC[C@H]1OC(O)C[C@@H](O)[C@@H]1O
Relative Density.	1.533 g/cm3

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (609.16 mM), Sonication is recommended.

DMSO: 60 mg/mL (365.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	304.5809 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	60.9162 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	30.4581 mL
20 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2290 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	6.0916 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0458 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc