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Anti-ASC/TMS1 Antibody (2P286)
🥰Excellent
Catalog No. TMAB-02862
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB,IHC-P,IHC-Fr,IF
Reactivity: Human
Anti-ASC/TMS1 Antibody (2P286)
Anti-ASC/TMS1 Antibody (2P286)
🥰Excellent
Catalog No. TMAB-02862
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB,IHC-P,IHC-Fr,IF
Reactivity: Human
Application: WB,IHC-P,IHC-Fr,IF
Reactivity: Human
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ASC/TMS1 Antibody (2P286) is a Rabbit antibody targeting ASC/TMS1. Anti-ASC/TMS1 Antibody (2P286) can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 2P286 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. |
| Tissue Specificity | Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Functions as a key mediator in apoptosis and inflammation.Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner.Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. |
| Immunogen | KLH conjugated synthetic peptide: human ASC |
| Antigen Species | Human |
| Gene Name | PYCARD |
| Gene ID | |
| Protein Name | Apoptosis-associated speck-like protein containing a CARD |
| Uniprot ID | |
| Function | Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. |
| Molecular Weight | Theoretical: 22 kDa. Actual: 22 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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